Nrf2

NFE2L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FLU, 2LZ1, 3ZGC, 4IFL
Identifiers
Aliases	NFE2L2, NRF2, HEBP1, nuclear factor, erythroid 2 like 2
External IDs	MGI: 108420 HomoloGene: 2412 GeneCards: NFE2L2
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • transcription regulatory region sequence-specific DNA binding • RNA polymerase II activating transcription factor binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • transcription regulatory region DNA binding • transcription cofactor binding • transcription factor binding Cellular component • cytoplasm • cytosol • centrosome • plasma membrane • protein-DNA complex • chromatin • nucleus • nucleoplasm • Golgi apparatus Biological process • positive regulation of glucose import • negative regulation of endothelial cell apoptotic process • negative regulation of hematopoietic stem cell differentiation • regulation of embryonic development • cellular response to glucose starvation • regulation of transcription, DNA-templated • cellular response to laminar fluid shear stress • positive regulation of transcription from RNA polymerase II promoter in response to stress • cellular response to tumor necrosis factor • proteasomal ubiquitin-independent protein catabolic process • negative regulation of cell death • cellular response to fluid shear stress • cell redox homeostasis • PERK-mediated unfolded protein response • positive regulation of glutathione biosynthetic process • transcription, DNA-templated • response to endoplasmic reticulum stress • positive regulation of ER-associated ubiquitin-dependent protein catabolic process • positive regulation of transcription, DNA-templated • endoplasmic reticulum unfolded protein response • cellular response to drug • positive regulation of gene expression • positive regulation of reactive oxygen species metabolic process • positive regulation of blood coagulation • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress • protein ubiquitination • cellular response to oxidative stress • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • negative regulation of hydrogen peroxide-induced cell death • inflammatory response • regulation of removal of superoxide radicals • positive regulation of transcription from RNA polymerase II promoter • cellular response to hydrogen peroxide • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of blood vessel endothelial cell migration • aging • cellular response to hypoxia • negative regulation of vascular associated smooth muscle cell migration • negative regulation of cardiac muscle cell apoptotic process • transcription from RNA polymerase II promoter • positive regulation of angiogenesis • positive regulation of neuron projection development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4780	18024
Ensembl	ENSG00000116044	ENSMUSG00000015839
UniProt	Q16236	Q60795
RefSeq (mRNA)	NM_006164 NM_001145412 NM_001145413 NM_001313900 NM_001313901 NM_001313902 NM_001313903 NM_001313904	NM_010902
RefSeq (protein)	NP_001138884 NP_001138885 NP_001300829 NP_001300830 NP_001300831 NP_001300832 NP_001300833 NP_006155	NP_035032.1 NP_035032
Location (UCSC)	Chr 2: 177.23 – 177.39 Mb	Chr 2: 75.68 – 75.7 Mb
PubMed search

2FLU, 2LZ1, 3ZGC, 4IFL

4780

18024

ENSG00000116044

ENSMUSG00000015839

Q16236

Q60795

NM_001313902
NM_001313903
NM_001313904

NM_010902

NP_001300832
NP_001300833
NP_006155

NP_035032.1
NP_035032

Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene. Nrf2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

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