Nitrosourea compounds

Nitrosourea

Names
IUPAC name Nitrosourea
Identifiers
CAS Number	13010-20-3 N
3D model (JSmol)	Interactive image Interactive image
ChemSpider	94772 Y
PubChem CID	105035
InChI InChI=1S/CH3N3O2/c2-1(5)3-4-6/h(H3,2,3,5,6) Y Key: OSTGTTZJOCZWJG-UHFFFAOYSA-N Y
SMILES NC(=O)N=NO C(=O)(N)NN=O
Properties
Chemical formula	CH3N3O2
Molar mass	89.05 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.

Examples include:

Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy. They are lipophilic and thus can cross the blood–brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.

Arabinopyranosyl-N-methyl-N-nitrosourea

Carmustine

Ethylnitrosourea

Fotemustine

Lomustine

N-Nitroso-N-methylurea

Nimustine

Ranimustine

Semustine

Streptozocin

Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease.