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Fotemustine

Fotemustine
Fotemustine.svg
Clinical data
Trade names Mustophoran
AHFS/Drugs.com International Drug Names
ATC code L01AD05 (WHO)
Identifiers
CAS Number 92118-27-9 N
PubChem (CID) 104799
DrugBank DB04106 N
ChemSpider 94600 YesY
UNII GQ7JL9P5I2 YesY
KEGG D07255 YesY
ChEMBL CHEMBL549386 YesY
ECHA InfoCard 100.158.792
Chemical and physical data
Formula C9H19ClN3O5P
Molar mass 315.691 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  

Fotemustine is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma. A study has shown that fotemustine produces improved response rates and but does not increase survival (over dacarbazine in the treatment of disseminated cutaneous melanoma. Median survival was 7.3 months with fotemustine versus 5.6 months with DTIC (P=.067). There was also toxicity prevalence in fotemustine arm. The main toxicity was grade 3 to 4 neutropenia (51% with fotemustine v 5% with DTIC) and thrombocytopenia (43% v 6%, respectively).


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Wikipedia

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