Coordinates: 31°00′43″S 138°13′41″E / 31.012°S 138.228°E
Nilpena Station is a pastoral lease that operates as a sheep station in South Australia.
It is situated approximately 44 kilometres (27 mi) west of Blinman and 99 kilometres (62 mi) north of Hawker in the Flinders Ranges and bounded by Lake Torrens. It occupies an area of 800 square kilometres (309 sq mi).
Thomas Elder and Robert Barr Smith acquired Nilpena in 1859.
William James Browne owned the property in 1879 when he had the drover Giles take 12,000 sheep from Nilpena and overland them all the way to his new properties Newcastle Waters and Delamere Stations. Only 8000 sheep survived the journey, but it was still regarded as one of the most remarkable droving feats in Australian history. Browne appointed Roderick John Matheson to manage the property, along with Arkaba Station. Matheson and John Lewis later bought Nilpena, with Matheson later buying out Lewis.