|
|||
Names | |||
---|---|---|---|
Preferred IUPAC name
Pyridine-3-carboxylic acid
|
|||
Other names | |||
Identifiers | |||
3D model (Jmol)
|
|||
3DMet | B00073 | ||
109591 | |||
ChEBI | |||
ChemSpider | |||
DrugBank | |||
ECHA InfoCard | 100.000.401 | ||
EC Number | 200-441-0 | ||
3340 | |||
KEGG | |||
MeSH | Niacin | ||
PubChem CID
|
|||
RTECS number | QT0525000 | ||
UNII | |||
|
|||
|
|||
Properties | |||
C 6NH 5O 2 |
|||
Molar mass | 123.1094 g mol−1 | ||
Appearance | White, translucent crystals | ||
Density | 1.473 g cm−3 | ||
Melting point | 237 °C; 458 °F; 510 K | ||
18 g L−1 | |||
log P | 0.219 | ||
Acidity (pKa) | 2.0,4.85 | ||
Isoelectric point | 4.75 | ||
Refractive index (nD)
|
1.4936 | ||
0.1271305813 D | |||
Thermochemistry | |||
Std enthalpy of
formation (ΔfH |
−344.9 kJ mol−1 | ||
Std enthalpy of
combustion (ΔcH |
−2.73083 MJ mol−1 | ||
Pharmacology | |||
C04AC01 (WHO) C10AD02 (WHO) | |||
Intramuscular, Oral | |||
Pharmacokinetics: | |||
20–45 min | |||
Hazards | |||
EU classification (DSD) (outdated)
|
Xi | ||
R-phrases (outdated) | R36/37/38 | ||
S-phrases (outdated) | S26, S36 | ||
NFPA 704 | |||
Flash point | 193 °C (379 °F; 466 K) | ||
365 °C (689 °F; 638 K) | |||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
|||
what is ?) | (|||
Infobox references | |||
Niacin, also known as nicotinic acid, is an organic compound with the formula C
6H
5NO
2 and, depending on the definition used, one of the 20 to 80 essential human nutrients. Together with nicotinamide it makes up the group known as vitamin B3 complex.
Medication and supplemental niacin are primarily used to treat high blood cholesterol and pellagra (niacin deficiency). Insufficient niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness. The lack of niacin may also be observed in pandemic deficiency disease, which is caused by a lack of five crucial vitamins (niacin, vitamin C, thiamin, vitamin D, and vitamin A) and is usually found in areas of widespread poverty and malnutrition. Niacin is provided in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods and meat from various animal sources. Some countries require its addition to grains.
This colorless, water-soluble solid is a derivative of pyridine, with a carboxyl group (COOH) at the 3-position. Other forms of vitamin B3 include the corresponding amide nicotinamide ("niacinamide"), where the carboxyl group has been replaced by a carboxamide group (CONH
2), as well as more complex amides and a variety of esters. Nicotinic acid and niacinamide are convertible to each other with steady world demand rising from 8,500 tonnes per year in the 1980s to 40,000 in recent years.