Neurotrophin-3

NTF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B8K, 1BND, 1NT3, 3BUK
Identifiers
Aliases	NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3
External IDs	MGI: 97380 HomoloGene: 1896 GeneCards: NTF3
Gene ontology Molecular function • neurotrophin p75 receptor binding • neurotrophin receptor binding • chemoattractant activity • growth factor activity • receptor binding Cellular component • extracellular region • cytoplasmic vesicle Biological process • regulation of apoptotic process • negative regulation of neuron apoptotic process • regulation of neuron differentiation • activation of protein kinase B activity • neuron projection morphogenesis • activation of GTPase activity • positive regulation of receptor internalization • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell migration • cell-cell signaling • positive regulation of peptidyl-serine phosphorylation • induction of positive chemotaxis • negative regulation of peptidyl-tyrosine phosphorylation • activation of MAPK activity • positive regulation of cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of actin cytoskeleton reorganization • signal transduction • positive chemotaxis • nervous system development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4908	18205
Ensembl	ENSG00000185652	ENSMUSG00000049107
UniProt	P20783	P20181
RefSeq (mRNA)	NM_001102654 NM_002527	NM_001164034 NM_001164035 NM_008742
RefSeq (protein)	NP_001096124 NP_002518	NP_001157506.1 NP_001157507.1 NP_032768.1 NP_001157506 NP_001157507 NP_032768
Location (UCSC)	Chr 12: 5.43 – 5.52 Mb	Chr 6: 126.1 – 126.17 Mb
PubMed search

1B8K, 1BND, 1NT3, 3BUK

4908

18205

ENSG00000185652

ENSMUSG00000049107

P20783

P20181

NM_001102654
NM_002527

NM_001164034
NM_001164035
NM_008742

NP_001096124
NP_002518

NP_032768

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.

The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor).

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Wikipedia