Neurotensin

NTS

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LNE, 2LNF, 2LNG, 2LYW, 3F6K, 2OYV, 2OYW, 4PO7

Identifiers

Aliases

NTS, NMN-125, NN, NT, NT/N, NTS1, neurotensin

External IDs

OMIM: 162650 MGI: 1328351 HomoloGene: 4506 GeneCards: NTS

Gene ontology
Molecular function	• neuropeptide hormone activity • protein binding
Cellular component	• extracellular region • transport vesicle • cytoplasmic vesicle • axon terminus
Biological process	• signal transduction • regulation of blood vessel size
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4922


67405

Ensembl


ENSG00000133636


ENSMUSG00000019890

UniProt


P30990 Q6FH20


Q9D3P9

RefSeq (mRNA)


NM_006183


NM_024435

RefSeq (protein)


NP_006174 NP_006174.1


NP_077755.1 NP_077755

Location (UCSC)

Chr 12: 85.87 – 85.88 Mb

Chr 10: 102.48 – 102.49 Mb

PubMed search

Neurotensin/neuromedin N precursor

Identifiers

Symbol

Pro-NT_NN

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Neurotensin
Identifiers

CAS Number	39379-15-2^Y
3D model (Jmol)	Interactive image
ChemSpider	17290409
PubChem	16133836
InChI InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 Key: PCJGZPGTCUMMOT-ISULXFBGSA-N InChI=1/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1
SMILES CC[C@H](C)[C@@H](/C(=N/[C@@H](CC(C)C)C(=O)O)/O)/N=C(/[C@H](Cc1ccc(cc1)O)/N=C(/[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)/N=C(/[C@H](CCCNC(=N)N)/N=C(/[C@@H]3CCCN3C(=O)[C@H](CCCCN)/N=C(/[C@H](CC(=N)O)/N=C(/[C@H](CCC(=O)O)/N=C(/[C@H](Cc4ccc(cc4)O)/N=C(\[C@H](CC(C)C)/N=C(\[C@@H]5CCC(=N5)O)/O)/O)\O)\O)\O)\O)\O)\O)\O
Properties
Chemical formula	C₇₈H₁₂₁N₂₁O₂₀
Molar mass	1672.92
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y (what is ^YN ?)
Infobox references

2LNE, 2LNF, 2LNG, 2LYW, 3F6K, 2OYV, 2OYW, 4PO7

NP_006174
NP_006174.1

NP_077755.1
NP_077755

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. Neurotensin was first isolated from extracts of bovine hypothalamus based on its ability to cause a visible vasodilation in the exposed cutaneous regions of anesthetized rats.

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