Neuroblastoma RAS viral oncogene homolog

NRAS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CON, 2N9C
Identifiers
Aliases	NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, Neuroblastoma RAS viral oncogene homolog, NRAS proto-oncogene, GTPase
External IDs	MGI: 97376 HomoloGene: 55661 GeneCards: NRAS
Gene ontology Molecular function • nucleotide binding • protein complex binding • GTP binding • GTPase activity Cellular component • Golgi apparatus • membrane • Golgi membrane • plasma membrane • extracellular exosome • tertiary granule membrane Biological process • epidermal growth factor receptor signaling pathway • stimulatory C-type lectin receptor signaling pathway • establishment of protein localization to Golgi • MAPK cascade • axon guidance • Fc-epsilon receptor signaling pathway • Ras protein signal transduction • leukocyte migration • signal transduction • ERBB2 signaling pathway • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4893	18176
Ensembl	ENSG00000213281	ENSMUSG00000027852
UniProt	P01111	P08556
RefSeq (mRNA)	NM_002524	NM_010937
RefSeq (protein)	NP_002515	n/a
Location (UCSC)	Chr 1: 114.7 – 114.72 Mb	Chr 3: 103.06 – 103.07 Mb
PubMed search

3CON, 2N9C

4893

18176

ENSG00000213281

ENSMUSG00000027852

P01111

P08556

NM_002524

NM_010937

NP_002515

n/a

NRAS is an enzyme that in humans is encoded by the NRAS gene. It was discovered by a small team of researchers led by Robin Weiss at the Institute of Cancer Research in London. It was the third RAS gene to be discovered, and was named NRAS, for its initial identification in human neuroblastoma cells.

The N-ras proto-oncogene is a member of the Ras gene family. It is mapped on chromosome 1, and it is activated in HL60, a promyelocytic leukemia line. The order of nearby genes is as follows: cen—CD2—NGFB—NRAS—tel.

The mammalian ras gene family consists of the harvey and kirsten ras genes (HRAS and KRAS), an inactive pseudogene of each (c-Hras2 and c-Kras1) and the N-ras gene. They differ significantly only in the C-terminal 40 amino acids. These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth.

...
Wikipedia