HRAS

HRAS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B30
Identifiers
Aliases	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase
External IDs	OMIM: 190020 MGI: 96224 HomoloGene: 55890 GeneCards: HRAS
Targeted by Drug
lonafarnib
Gene ontology Molecular function • nucleotide binding • GTP binding • protein C-terminus binding • protein binding • GTPase activity Cellular component • cytoplasm • cytosol • Golgi apparatus • intracellular membrane-bounded organelle • membrane • Golgi membrane • plasma membrane • perinuclear region of cytoplasm • nucleus Biological process • negative regulation of neuron apoptotic process • defense response to protozoan • positive regulation of protein phosphorylation • regulation of long-term neuronal synaptic plasticity • endocytosis • positive regulation of MAP kinase activity • epidermal growth factor receptor signaling pathway • protein heterooligomerization • positive regulation of miRNA metabolic process • positive regulation of epithelial cell proliferation • positive regulation of ruffle assembly • mitotic cell cycle checkpoint • positive regulation of cell migration • ephrin receptor signaling pathway • positive regulation of wound healing • positive regulation of Ras protein signal transduction • positive regulation of interferon-gamma production • stimulatory C-type lectin receptor signaling pathway • positive regulation of JNK cascade • negative regulation of gene expression • MAPK cascade • axon guidance • Fc-epsilon receptor signaling pathway • positive regulation of DNA replication • cell aging • intrinsic apoptotic signaling pathway • positive regulation of GTPase activity • chemotaxis • cell surface receptor signaling pathway • positive regulation of gene expression • negative regulation of GTPase activity • cell cycle arrest • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • T-helper 1 type immune response • Ras protein signal transduction • cell proliferation • T cell receptor signaling pathway • positive regulation of actin cytoskeleton reorganization • leukocyte migration • positive regulation of MAPK cascade • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • signal transduction • apoptotic process • small GTPase mediated signal transduction • ERBB2 signaling pathway • cellular senescence • response to isolation stress Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3265	15461
Ensembl	n/a	ENSMUSG00000025499
UniProt	P01112	Q61411
RefSeq (mRNA)	NM_001130442 NM_005343 NM_176795 NM_001318054	NM_001130443 NM_001130444 NM_008284
RefSeq (protein)	NP_001123914 NP_001304983 NP_005334 NP_789765	NP_001123915.1 NP_001123916.1 NP_032310.2 NP_001123915 NP_001123916 NP_032310
Location (UCSC)	Chr 11: 0.53 – 0.54 Mb	Chr 7: 141.19 – 141.19 Mb
PubMed search

121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B30

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