Neuregulin-1

NRG1

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1HAE, 1HAF, 1HRE, 1HRF, 3U7U

Identifiers

Aliases

NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF, neuregulin 1

External IDs

OMIM: 142445 HomoloGene: 8509 GeneCards: NRG1

Genetically Related Diseases

coronary artery disease, thyroid cancer, Hirschsprung's disease

Gene ontology
Molecular function	• transmembrane receptor protein tyrosine kinase activator activity • protein tyrosine kinase activator activity • receptor binding • cytokine activity • transcription cofactor activity • growth factor activity • protein binding • chemorepellent activity • receptor tyrosine kinase binding • ErbB-2 class receptor binding • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • ErbB-3 class receptor binding • Ras guanyl-nucleotide exchange factor activity • integrin binding
Cellular component	• cytoplasm • membrane • synapse • extracellular region • nucleus • apical plasma membrane • integral component of membrane • neuromuscular junction • plasma membrane • axon • cell body • integral component of plasma membrane • dendrite • axolemma • external side of plasma membrane • extracellular space • nucleoplasm
Biological process	• cardiac conduction system development • embryo development • positive regulation of Ras protein signal transduction • muscle organ development • oligodendrocyte differentiation • positive regulation of dendritic spine development • cellular protein complex disassembly • mammary gland development • axon ensheathment • cell communication • chemorepulsion involved in interneuron migration from the subpallium to the cortex • positive regulation of cardiac muscle cell proliferation • positive regulation of protein localization to cell surface • positive regulation of striated muscle cell differentiation • cell proliferation • positive regulation of protein kinase B signaling • locomotory behavior • negative regulation of protein catabolic process • transmembrane receptor protein tyrosine kinase signaling pathway • cardiac muscle cell differentiation • endocardial cell differentiation • heart development • positive regulation of cell growth • cardiac muscle cell myoblast differentiation • positive regulation of peptidyl-tyrosine phosphorylation • synapse assembly • positive regulation of cardiac muscle cell differentiation • positive regulation of axon extension • peripheral nervous system development • startle response • regulation of protein heterodimerization activity • wound healing • glial cell differentiation • nervous system development • ventricular trabecula myocardium morphogenesis • glial cell fate commitment • negative regulation of cardiac muscle cell apoptotic process • negative regulation of transcription, DNA-templated • regulation of protein homodimerization activity • neurotransmitter receptor metabolic process • phosphatidylinositol-mediated signaling • positive regulation of protein kinase activity • negative regulation of neuron migration • neurogenesis • neural crest cell development • positive regulation of protein targeting to mitochondrion • MAPK cascade • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of myelination • brain development • negative regulation of secretion • cell morphogenesis • regulation of cell differentiation • ventricular cardiac muscle cell differentiation • positive regulation of phosphatidylinositol 3-kinase signaling • neuron fate commitment • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • cell migration • positive regulation of cell adhesion • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • positive regulation of gene expression • positive regulation of cell proliferation • ERBB signaling pathway • activation of protein kinase B activity • activation of MAPK activity • regulation of cell motility • peptidyl-tyrosine phosphorylation • positive regulation of protein tyrosine kinase activity • ERBB2 signaling pathway • regulation of phosphatidylinositol 3-kinase signaling • activation of transmembrane receptor protein tyrosine kinase activity • cardiac muscle tissue development • negative regulation of ERBB signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3084


n/a

Ensembl


ENSG00000157168


n/a

UniProt


Q02297 Q7RTW3


n/a

RefSeq (mRNA)

NM_001159995 NM_001159996 NM_001159999 NM_001160001 NM_001160002
NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013959 NM_013960 NM_013962 NM_013964 NM_001322197 NM_001322201 NM_001322202 NM_001322205 NM_001322206 NM_001322207 NM_001322203


n/a

RefSeq (protein)

NP_001153467 NP_001153468 NP_001153471 NP_001153473 NP_001153474
NP_001153476 NP_001153477 NP_001153479 NP_001153480 NP_001309126 NP_001309130 NP_001309131 NP_001309132 NP_001309134 NP_001309135 NP_001309136 NP_004486 NP_039250 NP_039251 NP_039252 NP_039253 NP_039254 NP_039256 NP_039258 NP_039251.2 NP_001153471.1 NP_001309130.1


n/a

Location (UCSC)

Chr 8: 31.64 – 32.77 Mb

n/a

PubMed search

n/a

1HAE, 1HAF, 1HRE, 1HRF, 3U7U

3084

n/a

ENSG00000157168

n/a

Q02297
Q7RTW3

n/a

NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013959
NM_013960
NM_013962
NM_013964
NM_001322197
NM_001322201
NM_001322202
NM_001322205
NM_001322206
NM_001322207
NM_001322203

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