National Route 40, also known as RN40 or "Ruta 40", is a route in western Argentina, stretching from Punta Loyola near Rio Gallegos in Santa Cruz Province in the south to La Quiaca in Jujuy Province in the north. The route parallels the Andes mountains. The southern part of the route, a largely unpaved road through sparsely populated territory, has become a well-known adventure tourism journey, although there are plans to pave the whole road.
RN40 is the longest route in Argentina and one of the longest in the world alongside such routes as U.S. Route 66, Canada's Trans-Canada Highway, and Australia's Stuart Highway, more than 5,000 kilometres (3,100 mi) long. At its traditional southern end near the city of Río Gallegos, it starts at sea level. It then crosses 20 national parks, 18 major rivers, and 27 passes in the Andes. Route 40's highest point is 5,000 m (16,404 ft) in Abra del Acay in Salta Province.
The road crosses the provinces of Santa Cruz, Chubut, Río Negro, Neuquen, Mendoza, San Juan, La Rioja, Catamarca, Tucumán, Salta, and Jujuy.