NRF1

NRF1
Identifiers
Aliases	NRF1, ALPHA-PAL, nuclear respiratory factor 1
External IDs	MGI: 1332235 HomoloGene: 3674 GeneCards: NRF1
Gene ontology Molecular function • DNA binding • protein homodimerization activity • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • core promoter sequence-specific DNA binding • oxidoreductase activity Cellular component • extracellular exosome • nucleoplasm • cytosol • nucleus Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • mitochondrion organization • generation of precursor metabolites and energy • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4899	18181
Ensembl	ENSG00000106459	ENSMUSG00000058440
UniProt	Q16656	Q9WU00
RefSeq (mRNA)	NM_005011 NM_001040110 NM_001293163 NM_001293164	NM_001164226 NM_001164227 NM_001164228 NM_001164229 NM_001164230 NM_010938
RefSeq (protein)	NP_001035199 NP_001280092 NP_001280093 NP_005002	NP_001157698.1 NP_035068.3 NP_001157698 NP_001157699 NP_001157700 NP_001157701 NP_001157702 NP_035068
Location (UCSC)	Chr 7: 129.61 – 129.76 Mb	Chr 6: 30.05 – 30.15 Mb
PubMed search

4899

18181

ENSG00000106459

ENSMUSG00000058440

Q16656

Q9WU00

NM_005011
NM_001040110
NM_001293163
NM_001293164

NM_010938

NP_001035199
NP_001280092
NP_001280093
NP_005002

NP_001157701
NP_001157702
NP_035068

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.

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Wikipedia