NFE2L1

NFE2L1
Identifiers
Aliases	NFE2L1, LCR-F1, NRF1, TCF11, nuclear factor, erythroid 2 like 1
External IDs	MGI: 99421 HomoloGene: 20685 GeneCards: NFE2L1
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription cofactor activity • transcription regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription factor binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • protein domain specific binding • protein complex binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • nucleus • cytoplasm • cytosol • protein complex Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • transcription, DNA-templated • positive regulation of transcription, DNA-templated • heme biosynthetic process • erythrocyte differentiation • cellular response to oxidative stress • inflammatory response • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4779	18023
Ensembl	ENSG00000082641	ENSMUSG00000038615
UniProt	Q14494	Q61985
RefSeq (mRNA)	NM_003204 NM_001330261 NM_001330262	NM_001130450 NM_001130451 NM_001130452 NM_001130453 NM_001130454 NM_008686
RefSeq (protein)	NP_001317190 NP_001317191 NP_003195	NP_001123922.1 NP_032712.2 NP_001123922 NP_001123923 NP_001123924 NP_001123925 NP_001123926 NP_032712
Location (UCSC)	Chr 17: 48.05 – 48.06 Mb	Chr 11: 96.82 – 96.83 Mb
PubMed search

4779

18023

ENSG00000082641

ENSMUSG00000038615

Q14494

Q61985

NM_003204
NM_001330261
NM_001330262

NM_008686

NP_001317190
NP_001317191
NP_003195

NP_001123925
NP_001123926
NP_032712

Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by the NFE2L1 gene. Since NFE2L1 is referred to as Nrf1, it is often confused with nuclear respiratory factor 1 (Nrf1).

NFE2L1 is a cap ‘n’ collar, basic-leucine zipper (bZIP) transcription factor. Several isoforms of NFE2L1 have been described for both human and mouse genes. NFE2L1 was first cloned in yeast using a genetic screening method. NFE2L1 is ubiquitously expressed, and high levels of transcript are detected in the heart, kidney, skeletal muscle, fat, and brain. Four separate regions — an asparagine/serine/threonine, acidic domains near the N-terminus, and a serine-rich domain located near the CNC motif — are required for full transactivation function of NFE2L1. NFE2L1 is a key regulator of cellular functions including oxidative stress response, differentiation, inflammatory response, metabolism, and maintaining proteostasis.

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Wikipedia