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NRAS (gene)

NRAS
Protein NRAS PDB 121p.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, Neuroblastoma RAS viral oncogene homolog, NRAS proto-oncogene, GTPase
External IDs MGI: 97376 HomoloGene: 55661 GeneCards: NRAS
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002524

NM_010937

RefSeq (protein)

NP_002515

n/a

Location (UCSC) Chr 1: 114.7 – 114.72 Mb Chr 3: 103.06 – 103.07 Mb
PubMed search

3CON, 2N9C

NM_002524

NM_010937

NP_002515

n/a

NRAS is an enzyme that in humans is encoded by the NRAS gene. It was discovered by a small team of researchers led by Robin Weiss at the Institute of Cancer Research in London. It was the third RAS gene to be discovered, and was named NRAS, for its initial identification in human neuroblastoma cells.

The N-ras proto-oncogene is a member of the Ras gene family. It is mapped on chromosome 1, and it is activated in HL60, a promyelocytic leukemia line. The order of nearby genes is as follows: cen—CD2—NGFB—NRAS—tel.

The mammalian ras gene family consists of the harvey and kirsten ras genes (HRAS and KRAS), an inactive pseudogene of each (c-Hras2 and c-Kras1) and the N-ras gene. They differ significantly only in the C-terminal 40 amino acids. These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth.


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Wikipedia

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