NOX5

NOX5
Identifiers
Aliases	NOX5, NADPH oxidase 5
External IDs	HomoloGene: 41568 GeneCards: NOX5
Gene location (Human) Chr. Chromosome 15 (human) Band No data available Start 68,930,525 bp End 69,062,743 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • hydrogen ion channel activity • calcium ion binding • heme binding • oxidoreductase activity • flavin adenine dinucleotide binding • NADP binding • protein binding • superoxide-generating NADPH oxidase activity Cellular component • integral component of membrane • membrane • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • angiogenesis • cytokinesis • superoxide anion generation • positive regulation of reactive oxygen species metabolic process • regulation of fusion of sperm to egg plasma membrane • apoptotic process • ion transport • oxidation-reduction process • regulation of proton transport • cell proliferation • endothelial cell proliferation • cytokine secretion • proton transport • cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79400	n/a
Ensembl	ENSG00000255346	n/a
UniProt	Q96PH1	n/a
RefSeq (mRNA)	NM_001184779 NM_001184780 NM_024505	n/a
RefSeq (protein)	NP_001171708 NP_001171709 NP_078781	n/a
Location (UCSC)	Chr 15: 68.93 – 69.06 Mb	n/a
PubMed search		n/a

79400

n/a

ENSG00000255346

n/a

Q96PH1

n/a

NM_001184779
NM_001184780
NM_024505

n/a

NP_001171708
NP_001171709
NP_078781

n/a

NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene.

NOX5 is a novel NADPH oxidase that generates superoxide.

Nox5 interacts with c-abl, superoxide production leads to phosphorylation of c-abl, while inhibition of c-abl kinase activity inhibits Nox5 superoxide production.

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Wikipedia