Abl gene

ABL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AB2, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 3PYY, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD, 4TWP, 4WA9, 4XEY, 4YC8, 5DC9, 5DC4, 5DC0, 2O88, 5HU9
Identifiers
Aliases	ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, ABL, JTK7, bcr/abl, c-ABL, c-p150, v-abl
External IDs	OMIM: 189980 MGI: 87859 HomoloGene: 3783 GeneCards: ABL1
Targeted by Drug
bafetinib, bosutinib, dasatinib anhydrous, imatinib, nilotinib, ponatinib, saracatinib
Gene ontology Molecular function • actin monomer binding • protein domain specific binding • SH3 domain binding • kinase activity • protein C-terminus binding • receptor binding • ATP binding • protein kinase activity • nicotinate-nucleotide adenylyltransferase activity • non-membrane spanning protein tyrosine kinase activity • metal ion binding • proline-rich region binding • magnesium ion binding • transferase activity • actin filament binding • protein binding • syntaxin binding • protein kinase C binding • DNA binding • nucleotide binding • manganese ion binding • mitogen-activated protein kinase binding • protein tyrosine kinase activity Cellular component • cytoplasm • cytosol • nuclear membrane • membrane • extrinsic component of cytoplasmic side of plasma membrane • mitochondrion • actin cytoskeleton • perinuclear region of cytoplasm • cytoskeleton • nucleus • nucleolus • nucleoplasm • cell leading edge • nuclear body Biological process • positive regulation of protein phosphorylation • B-1 B cell homeostasis • regulation of axon extension • neuromuscular process controlling balance • positive regulation of muscle cell differentiation • cellular response to DNA damage stimulus • protein phosphorylation • regulation of cell adhesion • cellular protein modification process • positive regulation of interferon-gamma secretion • regulation of microtubule polymerization • DNA damage induced protein phosphorylation • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of ERK1 and ERK2 cascade • substrate adhesion-dependent cell spreading • platelet-derived growth factor receptor-beta signaling pathway • positive regulation of actin filament binding • B cell receptor signaling pathway • apoptotic process • negative regulation of endothelial cell apoptotic process • cerebellum morphogenesis • regulation of actin cytoskeleton reorganization • regulation of transcription, DNA-templated • epidermal growth factor receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • establishment of protein localization • thymus development • negative regulation of phospholipase C activity • positive regulation of mitotic cell cycle • actin filament branching • spleen development • response to oxidative stress • phagocytosis • positive regulation of peptidyl-tyrosine phosphorylation • regulation of response to DNA damage stimulus • mitochondrial depolarization • positive regulation of Wnt signaling pathway, planar cell polarity pathway • platelet-derived growth factor receptor signaling pathway • regulation of endocytosis • activation of protein kinase C activity • regulation of actin cytoskeleton organization • phosphorylation • signal transduction in response to DNA damage • positive regulation of oxidoreductase activity • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of I-kappaB kinase/NF-kappaB signaling • regulation of cell motility • positive regulation of microtubule binding • cell adhesion • regulation of autophagy • peptidyl-tyrosine autophosphorylation • alpha-beta T cell differentiation • regulation of cellular senescence • negative regulation of protein serine/threonine kinase activity • actin cytoskeleton organization • negative regulation of cellular senescence • positive regulation of osteoblast proliferation • mitotic nuclear division • activated T cell proliferation • endocytosis • negative regulation of cell-cell adhesion • B cell proliferation involved in immune response • positive regulation of interleukin-2 secretion • cellular response to dopamine • positive regulation of cytosolic calcium ion concentration • positive regulation of neuron death • regulation of cell cycle • negative regulation of BMP signaling pathway • autophagy • B cell proliferation • negative regulation of ubiquitin-protein transferase activity • cell cycle arrest • microspike assembly • positive regulation of apoptotic process • regulation of extracellular matrix organization • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of ERK1 and ERK2 cascade • transitional one stage B cell differentiation • mismatch repair • Bergmann glial cell differentiation • peptidyl-tyrosine phosphorylation • collateral sprouting • cellular response to lipopolysaccharide • negative regulation of mitotic cell cycle • cellular response to hydrogen peroxide • DNA repair • innate immune response • neural tube closure • post-embryonic development • neuron differentiation • cellular response to oxidative stress • regulation of cell proliferation • protein autophosphorylation • neuroepithelial cell differentiation • cardiovascular system development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25	11350
Ensembl	ENSG00000097007	ENSMUSG00000026842
UniProt	P00519	P00520
RefSeq (mRNA)	NM_007313 NM_005157	NM_001112703 NM_009594 NM_001283045 NM_001283046 NM_001283047
RefSeq (protein)	NP_005148 NP_009297	NP_001106174.1 NP_001269974.1 NP_001269975.1 NP_033724.2 NP_001106174 NP_001269974 NP_001269975 NP_001269976 NP_033724
Location (UCSC)	Chr 9: 130.71 – 130.89 Mb	Chr 2: 31.69 – 31.8 Mb
PubMed search

1AB2, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 3PYY, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD, 4TWP, 4WA9, 4XEY, 4YC8, 5DC9, 5DC4, 5DC0, 2O88, 5HU9

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