NOTCH4

NOTCH4
Identifiers
Aliases	NOTCH4, INT3, notch 4
External IDs	MGI: 107471 HomoloGene: 3351 GeneCards: NOTCH4
Genetically Related Diseases
schizophrenia, age related macular degeneration, asthma, systemic scleroderma
Gene ontology Molecular function • protein binding • protein heterodimerization activity • calcium ion binding • receptor activity Cellular component • integral component of membrane • cytosol • endoplasmic reticulum membrane • membrane • Golgi membrane • integral component of plasma membrane • nucleoplasm • extracellular region • cell surface • nucleus • plasma membrane Biological process • hemopoiesis • regulation of transcription, DNA-templated • embryo development • negative regulation of cell differentiation • endothelial cell morphogenesis • negative regulation of endothelial cell differentiation • morphogenesis of a branching structure • transcription, DNA-templated • mammary gland development • positive regulation of transcription, DNA-templated • multicellular organism development • positive regulation of transcription of Notch receptor target • branching involved in blood vessel morphogenesis • Notch receptor processing • cell fate determination • endothelial cell differentiation • transcription initiation from RNA polymerase II promoter • Notch signaling pathway • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4855	18132
Ensembl	n/a	ENSMUSG00000015468
UniProt	Q99466	P31695
RefSeq (mRNA)	NM_004557	NM_010929
RefSeq (protein)	NP_004548	NP_035059.2 NP_035059
Location (UCSC)	Chr 6: 32.19 – 32.22 Mb	Chr 17: 34.56 – 34.59 Mb
PubMed search

4855

18132

n/a

ENSMUSG00000015468

Q99466

P31695

NM_004557

NM_010929

NP_004548

NP_035059.2
NP_035059

Neurogenic locus notch homolog 4 also known as notch 4 is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6.

An alternative splice variant of the NOTCH4 gene has been described, but its biological significance has not been determined.

The neurogenic locus notch homolog 4 protein is a member of the Notch family. Members of this type 1 transmembrane protein family share structural characteristics. These include an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain that consists of multiple, but different, domain types.

Notch protein family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling pathway is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells

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