NOTCH2

NOTCH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OO4
Identifiers
Aliases	NOTCH2, AGS2, HJCYS, hN2, Notch-2, notch 2
External IDs	MGI: 97364 HomoloGene: 7865 GeneCards: NOTCH2
Gene ontology Molecular function • calcium ion binding • transcription factor activity, ligand-activated RNA polymerase II transcription factor binding • protein binding • receptor activity Cellular component • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • membrane • Golgi membrane • receptor complex • plasma membrane • integral component of plasma membrane • nucleoplasm • extracellular region • cell surface • nucleus Biological process • Notch signaling pathway • cell differentiation • hemopoiesis • pulmonary valve morphogenesis • regulation of transcription, DNA-templated • positive regulation of Ras protein signal transduction • negative regulation of apoptotic process • marginal zone B cell differentiation • transcription, DNA-templated • nervous system development • stem cell population maintenance • multicellular organism development • atrial septum morphogenesis • cell growth • regulation of developmental process • bone remodeling • cell cycle arrest • animal organ morphogenesis • transcription initiation from RNA polymerase II promoter • negative regulation of cell proliferation • Notch signaling involved in heart development • apoptotic process • cell fate determination • intracellular receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4853	18129
Ensembl	ENSG00000134250	ENSMUSG00000027878
UniProt	Q04721	O35516
RefSeq (mRNA)	NM_001200001 NM_024408	NM_010928
RefSeq (protein)	NP_001186930 NP_077719	NP_035058.2 NP_035058
Location (UCSC)	Chr 1: 119.91 – 120.07 Mb	Chr 3: 98.01 – 98.15 Mb
PubMed search

2OO4

4853

18129

ENSG00000134250

ENSMUSG00000027878

Q04721

O35516

NM_001200001
NM_024408

NM_010928

NP_001186930
NP_077719

NP_035058.2
NP_035058

Neurogenic locus notch homolog protein 2 also known as notch 2 is a protein that in humans is encoded by the NOTCH2 gene.

NOTCH2 is associated with Alagille syndrome and Hajdu–Cheney syndrome.

Notch 2 is a member of the notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.

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Wikipedia