NLGN1

NLGN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B3Q
Identifiers
Aliases	NLGN1, NL1, neuroligin 1
External IDs	MGI: 2179435 HomoloGene: 56690 GeneCards: NLGN1
Gene ontology Molecular function • PDZ domain binding • protein dimerization activity • cell adhesion molecule binding • scaffold protein binding • carboxylic ester hydrolase activity • neurexin family protein binding • receptor activity Cellular component • synapse • integral component of membrane • NMDA selective glutamate receptor complex • Golgi apparatus • cell junction • dendritic shaft • filopodium tip • dendritic spine • postsynaptic membrane • membrane • dendrite • excitatory synapse • external side of plasma membrane • cell surface • presynapse • postsynaptic density of dendrite • plasma membrane • integral component of postsynaptic membrane • integral component of plasma membrane Biological process • NMDA glutamate receptor clustering • positive regulation of ruffle assembly • positive regulation of synaptic vesicle exocytosis • regulation of AMPA receptor activity • rhythmic process • positive regulation of synaptic transmission, glutamatergic • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • positive regulation of circadian sleep/wake cycle, wakefulness • regulation of respiratory gaseous exchange by neurological system process • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • protein heterotetramerization • synaptic vesicle transport • terminal button organization • synapse organization • positive regulation of synaptic transmission, GABAergic • postsynaptic density protein 95 clustering • receptor localization to synapse • protein localization to synapse • neurexin clustering involved in presynaptic membrane assembly • positive regulation of synaptic vesicle endocytosis • synaptic vesicle targeting • protein homooligomerization • positive regulation of protein localization to synapse • neuron projection development • protein targeting • positive regulation of intracellular signal transduction • long-term synaptic potentiation • nervous system development • AMPA glutamate receptor clustering • neuronal signal transduction • synaptic vesicle clustering • positive regulation of synaptic vesicle clustering • cytoskeletal matrix organization at active zone • synapse assembly • establishment of protein localization • modulation of chemical synaptic transmission • positive regulation of filopodium assembly • cell adhesion • regulation of neuron differentiation • neuron cell-cell adhesion • positive regulation of dendritic spine development • regulation of NMDA receptor activity • positive regulation of excitatory postsynaptic potential • negative regulation of dendritic spine morphogenesis • positive regulation of synapse assembly • excitatory synapse assembly • positive regulation of presynaptic active zone assembly • retrograde trans-synaptic signaling by trans-synaptic protein complex • synaptic vesicle endocytosis • postsynaptic membrane assembly • presynaptic membrane assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22871	192167
Ensembl	ENSG00000169760	ENSMUSG00000063887
UniProt	Q8N2Q7	Q99K10
RefSeq (mRNA)	NM_014932	NM_001163387 NM_138666
RefSeq (protein)	NP_055747	NP_001156859 NP_619607
Location (UCSC)	Chr 3: 173.4 – 174.29 Mb	Chr 3: 25.43 – 26.33 Mb
PubMed search

3B3Q

22871

192167

ENSG00000169760

ENSMUSG00000063887

Q8N2Q7

Q99K10

NM_014932

NM_001163387
NM_138666

NP_055747

NP_001156859
NP_619607

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.

NLGN1 has been shown to interact with NRXN1 and DLG4.

...
Wikipedia