NKG2D

KLRK1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1KCG, 4PDC, 1HYR, 1MPU, 4S0U
Identifiers
Aliases	KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, killer cell lectin like receptor K1
External IDs	HomoloGene: 136440 GeneCards: KLRK1
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.2 Start 10,372,353 bp End 10,391,874 bp
Gene ontology Molecular function • protein homodimerization activity • protein binding • MHC class Ib receptor activity • MHC class I protein binding • carbohydrate binding • receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • cell surface • external side of plasma membrane • plasma membrane Biological process • cell differentiation • adaptive immune response • immune system process • positive regulation of nitric oxide biosynthetic process • negative regulation of natural killer cell chemotaxis • T cell costimulation • natural killer cell activation • positive regulation of interferon-gamma production • stimulatory C-type lectin receptor signaling pathway • negative regulation of GTPase activity • regulation of immune response • cellular response to lipopolysaccharide • positive regulation of natural killer cell mediated cytotoxicity • signal transduction • defense response to Gram-positive bacterium • innate immune response • natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22914	n/a
Ensembl	ENSG00000213809	n/a
UniProt	P26718	n/a
RefSeq (mRNA)	NM_007360	n/a
RefSeq (protein)	NP_031386	n/a
Location (UCSC)	Chr 12: 10.37 – 10.39 Mb	n/a
PubMed search		n/a

1KCG, 4PDC, 1HYR, 1MPU, 4S0U

22914

n/a

ENSG00000213809

n/a

P26718

n/a

NM_007360

n/a

NP_031386

n/a

NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors. NKG2D is encoded by KLRK1 gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans. In mice, it is expressed by NK cells, NK1.1⁺ T cells, γδ T cells, activated CD8⁺ αβ T cells and activated macrophages. In humans, it is expressed by NK cells, γδ T cells and CD8⁺ αβ T cells. NKG2D recognizes induced-self proteins from MIC and RAET1/ULBP families which appear on the surface of stressed, malignant transformed, and infected cells.

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