NK2 homeobox 1

NKX2-1
Identifiers
Aliases	NKX2-1, Nkx2-1, AV026640, Nkx2.1, T/EBP, Titf1, Ttf-1, BCH, BHC, NK-2, NKX2A, TEBP, TTF1, NMTC1, NK2 homeobox 1
External IDs	MGI: 108067 HomoloGene: 2488 GeneCards: NKX2-1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • core promoter binding • intronic transcription regulatory region DNA binding • transcription factor activity, sequence-specific DNA binding • intronic transcription regulatory region sequence-specific DNA binding • protein binding • enzyme binding • transcription regulatory region DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA polymerase II regulatory region DNA binding Cellular component • transcription factor complex • nucleoplasm • nucleus Biological process • pattern specification process • cerebral cortex GABAergic interneuron differentiation • developmental induction • Clara cell differentiation • endoderm development • pituitary gland development • Leydig cell differentiation • forebrain neuron fate commitment • regulation of transcription, DNA-templated • locomotory behavior • lung development • rhythmic process • regulation of transcription from RNA polymerase II promoter • anatomical structure formation involved in morphogenesis • forebrain dorsal/ventral pattern formation • oligodendrocyte differentiation • neuron migration • negative regulation of transcription from RNA polymerase II promoter • negative regulation of transforming growth factor beta receptor signaling pathway • globus pallidus development • transcription, DNA-templated • axon guidance • telencephalon cell migration • positive regulation of transcription, DNA-templated • thyroid gland development • brain development • positive regulation of gene expression • negative regulation of cell migration • telencephalon development • forebrain neuron differentiation • animal organ morphogenesis • response to hormone • phospholipid metabolic process • positive regulation of circadian rhythm • forebrain development • cerebral cortex neuron differentiation • neuron fate commitment • Type II pneumocyte differentiation • lung saccule development • negative regulation of transcription, DNA-templated • cerebral cortex cell migration • hippocampus development • epithelial tube branching involved in lung morphogenesis • negative regulation of epithelial to mesenchymal transition • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7080	21869
Ensembl	ENSG00000136352	ENSMUSG00000001496
UniProt	P43699	P50220
RefSeq (mRNA)	NM_001079668 NM_003317	NM_001146198 NM_009385
RefSeq (protein)	NP_001073136 NP_003308	NP_001139670.1 NP_033411.3 NP_001139670 NP_033411
Location (UCSC)	Chr 14: 36.52 – 36.52 Mb	Chr 12: 56.53 – 56.54 Mb
PubMed search

7080

21869

ENSG00000136352

ENSMUSG00000001496

P43699

P50220

NM_001079668
NM_003317

NM_001146198
NM_009385

NP_001073136
NP_003308

NP_001139670.1
NP_033411.3
NP_001139670
NP_033411

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.

Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and diencephalon. It is also known as thyroid specific enhancer binding protein. It is used in anatomic pathology as a marker to determine if a tumor arises from the lung or thyroid. NKX2.1 can be induced by activin A via SMAD2 signaling in a human embryonic stem cell differentiation model.

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Wikipedia