NFE2L3

NFE2L3
Identifiers
Aliases	NFE2L3, NRF3, nuclear factor, erythroid 2 like 3
External IDs	MGI: 1339958 HomoloGene: 3168 GeneCards: NFE2L3
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • transcription coactivator activity • sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • transcription regulatory region sequence-specific DNA binding Cellular component • cytoplasm • nucleus Biological process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9603	18025
Ensembl	ENSG00000050344	ENSMUSG00000029832
UniProt	Q9Y4A8	Q9WTM4
RefSeq (mRNA)	NM_004289	NM_010903
RefSeq (protein)	NP_004280	NP_035033.1 NP_035033
Location (UCSC)	Chr 7: 26.15 – 26.19 Mb	Chr 6: 51.43 – 51.46 Mb
PubMed search

9603

18025

ENSG00000050344

ENSMUSG00000029832

Q9Y4A8

Q9WTM4

NM_004289

NM_010903

NP_004280

NP_035033.1
NP_035033

Nuclear Factor (Erythroid 2) - Like Factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene.

This protein is a basic leucine zipper transcription factor belonging to the Cap ‘n’ Collar (CNC) family of proteins. In 1989, the first CNC transcription factor was identified, namely NFE2L2. After that, several other protein members have also been identified over the years like NRF1 and NRF3 in different organisms like humans, mice and zebrafish. These proteins are specifically encoded in the humans by Nfe2l1 and Nfe2l3 genes respectively.

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Wikipedia