NFE2

NFE2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KZ5
Identifiers
Aliases	NFE2, NF-E2, p45, nuclear factor, erythroid 2
External IDs	MGI: 97308 HomoloGene: 4491 GeneCards: NFE2
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 54,292,111 bp End 54,301,121 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F3|15 58.62 cM Start 103,248,212 bp End 103,258,403 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein N-terminus binding • transcription coactivator activity • transcription regulatory region sequence-specific DNA binding • protein binding • WW domain binding • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • core promoter proximal region sequence-specific DNA binding Cellular component • cytoplasm • PML body • nucleus • nucleoplasm • protein-DNA complex Biological process • hemostasis • regulation of transcription, DNA-templated • blood coagulation • blood circulation • transcription, DNA-templated • multicellular organism development • positive regulation of transcription, DNA-templated • nucleosome disassembly • regulation of transcription from RNA polymerase II promoter • regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4778	18022
Ensembl	ENSG00000123405	ENSMUSG00000058794
UniProt	Q16621	Q07279
RefSeq (mRNA)	NM_001136023 NM_001261461 NM_006163	NM_008685 NM_001302338 NM_001302339 NM_001302340 NM_001302341 NM_001302343
RefSeq (protein)	NP_001129495 NP_001248390 NP_006154	NP_001289267 NP_001289268 NP_001289269 NP_001289270 NP_001289272 NP_032711
Location (UCSC)	Chr 12: 54.29 – 54.3 Mb	Chr 12: 103.25 – 103.26 Mb
PubMed search

2KZ5

4778

18022

ENSG00000123405

ENSMUSG00000058794

Q16621

Q07279

NM_001136023
NM_001261461
NM_006163

NM_001302343

NP_001129495
NP_001248390
NP_006154

NP_032711

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.

It is involved in megakaryocyte production.

NFE2 has been shown to interact with CREB-binding protein.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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