NEFM

NEFM
Identifiers
Aliases	NEFM, NEF3, NF-M, NFM, neurofilament, medium polypeptide, neurofilament medium
External IDs	HomoloGene: 38041 GeneCards: NEFM
Gene ontology Molecular function • microtubule binding • structural constituent of cytoskeleton • protein binding • structural molecule activity Cellular component • neurofibrillary tangle • axon • intermediate filament • neurofilament Biological process • neurofilament bundle assembly • axon development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4741	n/a
Ensembl	ENSG00000104722	n/a
UniProt	P07197	n/a
RefSeq (mRNA)	NM_005382 NM_001105541	n/a
RefSeq (protein)	NP_001099011 NP_005373	n/a
Location (UCSC)	Chr 8: 24.91 – 24.92 Mb	n/a
PubMed search		n/a

4741

n/a

ENSG00000104722

n/a

P07197

n/a

NM_005382
NM_001105541

n/a

NP_001099011
NP_005373

n/a

Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.

Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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