NEFL

NEFL
Identifiers
Aliases	NEFL, CMT1F, CMT2E, NF-L, NF68, NFL, PPP1R110, neurofilament, light polypeptide
External IDs	MGI: 97313 HomoloGene: 4487 GeneCards: NEFL
Gene ontology Molecular function • protein binding, bridging • phospholipase binding • protein domain specific binding • structural molecule activity • structural constituent of cytoskeleton • protein C-terminus binding • protein binding • identical protein binding • protein heterodimerization activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • neurofilament • growth cone • myelin sheath • TSC1-TSC2 complex • axon • neuron projection • intermediate filament • axon cytoplasm Biological process • negative regulation of neuron apoptotic process • retrograde axonal transport • intermediate filament organization • response to sodium arsenite • neuron projection morphogenesis • protein polymerization • intermediate filament bundle assembly • neuromuscular process controlling balance • neurofilament bundle assembly • response to corticosterone • response to peptide hormone • response to organic substance • positive regulation of axonogenesis • MAPK cascade • anterograde axonal transport • axonal transport of mitochondrion • regulation of axon diameter • peripheral nervous system axon regeneration • locomotion • response to acrylamide • spinal cord development • cerebral cortex development • intermediate filament polymerization or depolymerization • neurofilament cytoskeleton organization • hippocampus development • response to toxic substance • microtubule cytoskeleton organization • positive regulation of GTPase activity • axon development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4747	18039
Ensembl	ENSG00000277586	ENSMUSG00000022055
UniProt	P07196	P08551
RefSeq (mRNA)	NM_006158	NM_010910
RefSeq (protein)	NP_006149	NP_035040.1 NP_035040
Location (UCSC)	Chr 8: 24.95 – 24.96 Mb	Chr 14: 68.08 – 68.09 Mb
PubMed search

4747

18039

ENSG00000277586

ENSMUSG00000022055

P07196

P08551

NM_006158

NM_010910

NP_006149

NP_035040.1
NP_035040

Neurofilament light polypeptide is a protein that in humans is encoded by the NEFL gene.

It is associated with Charcot–Marie–Tooth disease 1F and 2E.

NEFL has been shown to interact with:

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Wikipedia