NAChRα9

CHRNA9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4D01, 4UXU, 4UY2
Identifiers
Aliases	CHRNA9, HSA243342, NACHRA9, cholinergic receptor nicotinic alpha 9 subunit
External IDs	MGI: 1202403 HomoloGene: 9729 GeneCards: CHRNA9
Targeted by Drug
muscarine
Gene ontology Molecular function • ion channel activity • calcium channel activity • extracellular ligand-gated ion channel activity • ligand-gated ion channel activity • acetylcholine-gated cation-selective channel activity Cellular component • synapse • integral component of membrane • cell junction • integral component of plasma membrane • postsynaptic membrane • membrane • acetylcholine-gated channel complex • plasma membrane Biological process • calcium ion transport • detection of mechanical stimulus involved in sensory perception of sound • positive regulation of cytosolic calcium ion concentration • inner ear morphogenesis • sensory perception of sound • ion transport • calcium ion transmembrane transport • transport • cation transport • regulation of postsynaptic membrane potential • excitatory postsynaptic potential Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55584	231252
Ensembl	ENSG00000174343	ENSMUSG00000029205
UniProt	Q9UGM1	n/a
RefSeq (mRNA)	NM_017581	NM_001081104
RefSeq (protein)	NP_060051	n/a
Location (UCSC)	Chr 4: 40.34 – 40.36 Mb	Chr 5: 65.93 – 65.98 Mb
PubMed search

4D01, 4UXU, 4UY2

55584

231252

ENSG00000174343

ENSMUSG00000029205

Q9UGM1

n/a

NM_017581

NM_001081104

NP_060051

n/a

Neuronal acetylcholine receptor subunit alpha-9, also known as nAChRα9, is a protein that in humans is encoded by the CHRNA9 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.

Selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.

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Wikipedia