NAChRα10

CHRNA10
Identifiers
Aliases	CHRNA10
External IDs	MGI: 3609260 HomoloGene: 56886 GeneCards: CHRNA10
Targeted by Drug
muscarine
Gene ontology Molecular function • calcium channel activity • ion channel activity • receptor binding • extracellular ligand-gated ion channel activity • acetylcholine-gated cation-selective channel activity Cellular component • integral component of membrane • perikaryon • postsynaptic membrane • membrane • plasma membrane • synapse • axon • cell junction • acetylcholine-gated channel complex Biological process • positive regulation of cytosolic calcium ion concentration • synaptic transmission, cholinergic • ion transport • detection of mechanical stimulus involved in sensory perception of sound • regulation of cell proliferation • calcium ion transmembrane transport • inner ear morphogenesis • transport • calcium ion transport • regulation of postsynaptic membrane potential • excitatory postsynaptic potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57053	504186
Ensembl	ENSG00000129749	ENSMUSG00000066279
UniProt	Q9GZZ6	n/a
RefSeq (mRNA)	NM_001303034 NM_001303035 NM_020402	NM_001081424
RefSeq (protein)	NP_001289963 NP_001289964 NP_065135	n/a
Location (UCSC)	Chr 11: 3.67 – 3.67 Mb	Chr 7: 102.11 – 102.12 Mb
PubMed search

57053

504186

ENSG00000129749

ENSMUSG00000066279

Q9GZZ6

n/a

NM_001303034
NM_001303035
NM_020402

NM_001081424

NP_001289963
NP_001289964
NP_065135

n/a

Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system. Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.

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Wikipedia