Myogenin

MYOG
Identifiers
Aliases	MYOG, MYF4, bHLHc3, myf-4, myogenin (myogenic factor 4)
External IDs	OMIM: 159980 MGI: 97276 HomoloGene: 1854 GeneCards: MYOG
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein dimerization activity • core promoter binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • core promoter proximal region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • E-box binding • protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin DNA binding Cellular component • transcription factor complex • protein-DNA complex • nucleus • nucleoplasm Biological process • cellular response to retinoic acid • positive regulation of myotube differentiation • cell differentiation • myotube differentiation • negative regulation of glycolytic process • regulation of transcription, DNA-templated • cellular response to lithium ion • ossification • positive regulation of muscle cell differentiation • response to muscle activity involved in regulation of muscle adaptation • muscle cell fate commitment • cellular response to growth factor stimulus • cellular response to estradiol stimulus • positive regulation of oxidative phosphorylation • muscle organ development • striated muscle atrophy • mRNA transcription from RNA polymerase II promoter • cellular response to magnetism • positive regulation of skeletal muscle fiber development • transcription, DNA-templated • multicellular organism development • positive regulation of transcription, DNA-templated • response to gravity • positive regulation of myoblast fusion • positive regulation of muscle atrophy • skeletal muscle tissue regeneration • positive regulation of myoblast differentiation • skeletal muscle fiber development • response to electrical stimulus involved in regulation of muscle adaptation • skeletal muscle atrophy • skeletal muscle cell differentiation • response to denervation involved in regulation of muscle adaptation • cell cycle • regulation of myoblast fusion • myoblast differentiation • regulation of skeletal muscle satellite cell proliferation • skeletal muscle tissue development • response to muscle activity • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • positive regulation of cell cycle arrest Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4656	17928
Ensembl	ENSG00000122180	ENSMUSG00000026459
UniProt	P15173	P12979
RefSeq (mRNA)	NM_002479	NM_031189
RefSeq (protein)	NP_002470	NP_112466.1 NP_112466
Location (UCSC)	Chr 1: 203.08 – 203.09 Mb	Chr 1: 134.29 – 134.29 Mb
PubMed search

4656

17928

ENSG00000122180

ENSMUSG00000026459

P15173

P12979

NM_002479

NM_031189

NP_002470

NP_112466.1
NP_112466

Myogenin (myogenic factor 4), also known as MYOG, is a gene.

Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and Mrf4.

In mice, myogenin is essential for the development of functional skeletal muscle. Myogenin is required for the proper differentiation of most myogenic precursor cells during the process of myogenesis. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.

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Wikipedia