MyoD

MYOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MDY
Identifiers
Aliases	MYOD1, MYF3, MYOD, PUM, bHLHc1, myogenic differentiation 1
External IDs	OMIM: 159970 MGI: 97275 HomoloGene: 7857 GeneCards: MYOD1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein dimerization activity • core promoter binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding • chromatin binding • nuclear hormone receptor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • E-box binding • protein binding • protein heterodimerization activity • enzyme binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin DNA binding • ubiquitin protein ligase binding • transcription coactivator activity Cellular component • transcription factor complex • nucleoplasm • myofibril • nuclear chromatin • nucleus • cytoplasm • cytosol • nuclear body Biological process • cell differentiation • myotube differentiation • regulation of transcription, DNA-templated • positive regulation of muscle cell differentiation • regulation of transcription from RNA polymerase II promoter • cellular response to starvation • muscle cell fate commitment • cellular response to estradiol stimulus • skeletal muscle fiber adaptation • muscle organ development • regulation of alternative mRNA splicing, via spliceosome • myotube cell development • positive regulation of skeletal muscle fiber development • negative regulation of myoblast proliferation • transcription, DNA-templated • multicellular organism development • positive regulation of transcription, DNA-templated • protein phosphorylation • regulation of RNA splicing • positive regulation of myoblast fusion • myoblast fate determination • cellular response to glucocorticoid stimulus • positive regulation of myoblast differentiation • skeletal muscle fiber development • histone H3 acetylation • myotube differentiation involved in skeletal muscle regeneration • histone H4 acetylation • skeletal muscle cell differentiation • positive regulation of skeletal muscle tissue regeneration • regulation of gene expression • striated muscle cell differentiation • cellular response to oxygen levels • myoblast fusion • myoblast differentiation • skeletal muscle tissue development • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4654	17927
Ensembl	ENSG00000129152	ENSMUSG00000009471
UniProt	P15172	P10085
RefSeq (mRNA)	NM_002478	NM_010866
RefSeq (protein)	NP_002469	NP_034996.2 NP_034996
Location (UCSC)	Chr 11: 17.72 – 17.72 Mb	Chr 7: 46.38 – 46.38 Mb
PubMed search

1MDY

4654

17927

ENSG00000129152

ENSMUSG00000009471

P15172

P10085

NM_002478

NM_010866

NP_002469

NP_034996.2
NP_034996

MyoD is a protein that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 (Myf6).

...
Wikipedia