Muscarinic acetylcholine receptor M5

CHRM5
Identifiers
Aliases	CHRM5, HM5, cholinergic receptor muscarinic 5
External IDs	OMIM: 118496 MGI: 109248 HomoloGene: 22697 GeneCards: CHRM5
Targeted by Drug
acetylcholine, milameline, pilocarpine, sabcomeline, xanomeline, brucine, VU0238429, AFDX384, amitriptyline, biperiden, darifenacin, glycopyrrolate, hexocyclium, himbacine, methoctramine free base, oxybutynin, pirenzepine, 3-quinuclidinyl-benzilate, tolterodine,
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • phosphatidylinositol phospholipase C activity • G-protein coupled acetylcholine receptor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • cell junction Biological process • G-protein coupled acetylcholine receptor signaling pathway • regulation of phosphatidylinositol dephosphorylation • G-protein coupled receptor signaling pathway • gastric acid secretion • transmission of nerve impulse • synaptic transmission, cholinergic • adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway • dopamine transport • phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway • cell proliferation • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1133	213788
Ensembl	ENSG00000184984	ENSMUSG00000074939
UniProt	P08912	Q920H4
RefSeq (mRNA)	NM_012125 NM_001320917	NM_205783
RefSeq (protein)	NP_001307846 NP_036257	NP_991352.2 NP_991352
Location (UCSC)	Chr 15: 33.97 – 34.07 Mb	Chr 2: 112.48 – 112.48 Mb
PubMed search

1133

213788

ENSG00000184984

ENSMUSG00000074939

P08912

Q920H4

NM_012125
NM_001320917

NM_205783

NP_001307846
NP_036257

NP_991352.2
NP_991352

The human muscarinic acetylcholine receptor M₅, encoded by the CHRM5 gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins. It is coupled to G_q protein. Binding of the endogenous ligand acetylcholine to the M₅ receptor triggers a number of cellular responses such as adenylate cyclase inhibition, phosphoinositide degradation, and potassium channel modulation. Muscarinic receptors mediate many of the effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor have not been fully explored; however, stimulation of this receptor is known to effectively decrease cyclic AMP levels and downregulate the activity of protein kinase A (PKA).

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