Moshe Wolman
| Moshe Wolman | |
|---|---|
Wolman, 1999
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| Born |
October 28, 1914 Warsaw, Poland |
| Died | September 5, 2009 (aged 94) Israel |
Moshe Wolman (November 10, 1914 – September 5, 2009) was an Israeli neuropathologist. He is considered one of the fathers of histochemistry. In 1954, he described Wolman's disease.
Moshe Wolman was born in 1914 in Warsaw, Poland. He immigrated to Mandate Palestine in 1925. He grew up in Tel Aviv and graduated from the prestigious Herzliya Gymnasium (academic secondary school). He studied medicine in Italy (Florence 1932-1935 and Rome, 1935–1938). In 1939, he married Brigitte "Bigi" Koebbel with whom he had four children: filmmaker Dan Wolman, philosopher Ruth Manor (1944–2005), psychiatrist Naomi Oren, and composer Amnon Wolman.
From 1938 to 1940, he worked in the Cancer Research Institute of the Hebrew University and did residency at the department of Internal Medicine of the Hadassah Hospital. In the 1940s, he volunteered to serve in the British Army and joined the 101 Military Mission (the famous Gideon Force of Orde Wingate). He was involved in the operation in 1941 that brought Emperor Haile Selassie back to occupied Ethiopia and was in charge of a medical ward and clinical laboratory in the Menelik Hospital in Addis Ababa in 1941-1944. In 1944, he was posted in the Central Pathology Laboratory of the Middle East Forces located in Cairo, Egypt. In 1945 he was appointed as head of the Pathology Laboratory of the 27th General Hospital in Tel-El-Kabir, Egypt.
After his release from the army in 1946, Wolman joined the department of Pathology of the Hadassah Hospital in Jerusalem and was involved in histochemical research. He taught at the newly founded Medical School of the Hebrew University. In this period, he studied the chemical significance of the periodic acid-Schiff (PAS) staining method and showed that the method is not specific for carbohydrates as was thought at the time, but also stains lipids.
In 1951 his research included histochemistry of viral and non-viral inclusion bodies and he continued to study chemical fixatives and fixation techniques. He showed that proteoglycans and polysaccharides of different pK values in their end groups can be differently stained which resulted in the development of Bi-Col procedure (Wolman, 1956). In fact, advances in our understanding of the chemical nature of ground substance remained largely neglected for a generation.
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