Mosbach Abbey (Kloster Mosbach) was a Benedictine monastery, later a monastery of Augustinian Canons, in the town of Mosbach in the Odenwald, Baden-Württemberg, Germany.
As part of the systematic Carolingian Christianisation of this part of Germany, a number of monasteries were set up, covering between them the whole region of the Odenwald: Amorbach, Lorsch and Fulda, all founded in the 8th century, and Mosbach, the southernmost and least documented. It is first mentioned in a reference in the records of Reichenau Abbey in 825, but in the context of the other monastic foundations in the Odenwald, it seems likely that it was also founded in the previous century. The next record of it is in 976, when Emperor Otto II granted it to Worms Cathedral chapter as a private episcopal monastery. In about 1000, it was changed from a Benedictine house to one of canons regular. In 1268 however the abbey regained its independence with the re-grant of the right to elect its own abbots.
In 1308 the present Saint Juliana's church was built to replace the earlier abbey church. In 1556 in the course of the Reformation the Elector Palatine Otto-Heinrich abolished Roman Catholic services and made the abbey church the town's Protestant parish church. The former Catholic parish church of Saint Cecilia's was thus rendered superfluous and was demolished. Otto-Heinrich dissolved the abbey itself in 1564, of which virtually nothing remains except the church.