Mook en Middelaar (Dutch pronunciation: [ˈmoːk ən ˈmɪdəlaːr], Limburgish: Mook en Middelar) is a municipality in the upper southeastern part of the Netherlands, at the northern tip of the province of Limburg and is a part of Stadsregio Arnhem Nijmegen. The municipality is located about 100 km from provincial capital Maastricht and has an area of 18.81 km² (7.26 sq mi) of which 1.42 km² (0.55 sq mi) is water.

The municipality is situated in wooded rolling moraine landscape, created during the last Ice Age, about 160,000 years ago.

In Plasmolen the remains of a Roman villa from the 2nd century AD were found and on the banks of the Meuse are the remains of a Roman bridge. These remains are from the 4th century.

The Mookerheide ("Mook Heath"), situated on the border of Mook, saw the Battle of Mookerheyde in 1574 which was fought as part of the Eighty Years War. Spanish forces under Sancho d'Avila defeated the rebel forces of Louis of Nassau, who was killed.

The Mookerschans and Heumense schans were defenses on the Mookerheide probably from the 17th century. (At that time the Mookerheide area extended all the way to the citywalls of Nijmegen) The historical Mookerheideschans (defense work) has been restored and offers a beautiful view over the Meuse valley.

Middelaar belonged to Overkwartier (Upper Quarter) of Guelders or Upper Guelders. During the War of the Spanish Succession Middelaar was occupied by Prussian troops, and it remained German for about a century (until 1814).

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