Metallothionein-3

MT3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2F5H, 2FJ4, 2FJ5
Identifiers
Aliases	MT3, GIF, GIFB, GRIF, Znmetallothionein 3
External IDs	HomoloGene: 136800 GeneCards: MT3
Gene location (Human) Chr. Chromosome 16 (human) Band 16q13 Start 56,589,074 bp End 56,591,088 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • protein kinase activator activity • metal ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • antioxidant activity • protein binding • drug binding • copper ion binding • cadmium ion binding Cellular component • cytoplasm • cytosol • rough endoplasmic reticulum • ribosome • astrocyte end-foot • postsynaptic density • synaptic vesicle • plasma membrane • dendritic spine • astrocyte projection • intracellular • mitochondrial outer membrane • axon • inclusion body • perinuclear region of cytoplasm • microtubule • extracellular space Biological process • negative regulation of neuron apoptotic process • positive regulation of necrotic cell death • cellular lipid catabolic process • positive regulation of vascular endothelial growth factor receptor signaling pathway • activation of protein kinase B activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein phosphorylation • positive regulation of cell death • response to hypoxia • zinc ion homeostasis • protein kinase B signaling • histone modification • leptin-mediated signaling pathway • removal of superoxide radicals • astrocyte development • ERK1 and ERK2 cascade • negative regulation of neurogenesis • regulation of response to food • protein import into nucleus, translocation • protein stabilization • zinc II ion transport • response to metal ion • negative regulation of apoptotic process • positive regulation of catalytic activity • cholesterol catabolic process • cellular response to cadmium ion • cellular metal ion homeostasis • cadmium ion homeostasis • response to oxidative stress • negative regulation of hydrogen peroxide catabolic process • negative regulation of cysteine-type endopeptidase activity • positive regulation of transcription, DNA-templated • cellular response to drug • brain development • positive regulation of gene expression • positive regulation of lysosomal membrane permeability • cellular zinc ion homeostasis • negative regulation of cell growth • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress • negative regulation of oxidoreductase activity • regulation of protein glycosylation • positive regulation of ERK1 and ERK2 cascade • positive regulation of oxygen metabolic process • cellular response to oxidative stress • cellular response to nitric oxide • negative regulation of reactive oxygen species metabolic process • energy reserve metabolic process • cell proliferation • negative regulation of autophagy • negative regulation of transcription, DNA-templated • negative regulation of axon extension • negative regulation of necrotic cell death • cellular response to hypoxia • negative regulation of neuron death • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4504	n/a
Ensembl	ENSG00000087250	n/a
UniProt	P25713	n/a
RefSeq (mRNA)	NM_005954	n/a
RefSeq (protein)	NP_005945	n/a
Location (UCSC)	Chr 16: 56.59 – 56.59 Mb	n/a
PubMed search		n/a

2F5H, 2FJ4, 2FJ5

4504

n/a

ENSG00000087250

n/a

P25713

n/a

NM_005954

n/a

NP_005945

n/a

Metallothionein-3 (also known as Growth Inhibitory Factor) is a protein that in humans is encoded by the MT3 gene. It is a 68-amino acid peptide (20 of which are cysteine) that is abnormally under-expressed in the brains of patients suffering from Alzheimer's disease. Metallothionein-3 is a member of the metallothionein family of proteins.

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