Mesa de Ocaña is a comarca in Castilla-La Mancha, Spain, in the province of Toledo. Its capital and administrative center is Ocaña. The comarca is located in the northeast part of the province, and encompasses an area that includes several hundred meters of the Tajo River Valley.

The comarca is bordered on the North by Aranjuez (Las Vegas); to the south by Los Yébenes and the Mancha Alta de Toledo (comarca) () comarca; to the West by La Sagra and Toledo; and to the East by the Mancha Alta de Toledo and La Mancha de Cuenca (comarca) ().

The altitude changes radically through the region. The height differences between the escarpments of the banks of the Tajo river to the North versus the steppes of La Guardia, and between the valleys and ravines of the Algodor River to the West and those of the Cedrón River to the East, have given rise the region's nickname of "the staircase." The area has a very distinct and unique set of geological formations which set it apart from its neighbors.

The comarca consists of 1,453.49 km², and contains the following municipalities: Cabañas de Yepes (17.97 km²), Ciruelos(22.94 km²), Dosbarrios (111.59 km²), La Guardia (195.59 km²), Huerta de Valdecarábanos (83.00 km²), Noblejas (69.67 km²), Ocaña (147.91 km²), Ontígola (41.49 km²), Santa Cruz de la Zarza (264.54 km²), Villarrubia de Santiago (155.29 km²), Villasequilla (76.95 km²), Villatobas (181.58 km²), and Yepes (84.97 km²).

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