Merlin Crossley

Professor Merlin Crossley is an Australian molecular biologist, university teacher and administrator. In 2016 he was appointed as Deputy Vice-Chancellor Education at the University of New South Wales (UNSW).

He attended Mount View Primary School, Glen Waverley, Victoria, then was awarded an entrance scholarship to Melbourne Grammar School, where he was dux. He undertook a Bachelor of Science at the University of Melbourne, as a resident of Queen's College (University of Melbourne), then a doctorate at the University of Oxford supported by a Rhodes Scholarship at Magdalen College, Oxford. He worked at Oxford, Harvard and the University of Sydney, before moving to UNSW as Dean of Science.

Crossley is interested in gene regulation. He studied an unusual genetic disorder termed Haemophilia B Leyden where patients recover after puberty. The condition results from mutations that disrupt the control region of the clotting factor IX gene. A testosterone responsive element accounts for post-pubertal recovery. He has also investigated abnormal patterns of globin gene expression and his work on mutations associated with the lifelong expression of the foetal haemoglobin gene may help in the treatment of thalassemia and sickle cell anaemia. He is using CRISPR-mediated gene editing to introduce beneficial mutations in cell lines as models for treating genetic diseases.

He is also known for the initial identification and cloning of a significant number of genes encoding DNA-binding proteins and their associated co-regulators, KLF3,KLF8,KLF17, EOS IKZF4, PEGASUS, FOG1 ZFPM1, FOG2 ZFPM2, and CTBP2.

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