KLF17

Identifiers

KLF17, ZNF393, Zfp393, Kruppel-like factor 17, Kruppel like factor 17

External IDs

MGI: 2181068 HomoloGene: 12621 GeneCards: KLF17

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription regulatory region DNA binding • DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • metal ion binding • nucleic acid binding
Cellular component	• nucleus
Biological process	• regulation of transcription from RNA polymerase II promoter • gamete generation • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • GO:0006350 transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


128209


75753

Ensembl


ENSG00000171872


ENSMUSG00000048626

UniProt


Q5JT82


Q8CFA7

RefSeq (mRNA)


NM_173484


NM_029416

RefSeq (protein)


NP_775755


NP_083692.2 NP_083692

Location (UCSC)

Chr 1: 44.12 – 44.14 Mb

Chr 4: 117.76 – 117.77 Mb

PubMed search

NP_083692.2
NP_083692

Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.

Model organisms have been used in the study of KLF17 function. A conditional knockout mouse line called Klf17^{tm1b(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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