Mediha Sultan (30 July 1856 – 7 January 1928) was an Ottoman princess, the daughter of Sultan Abdülmecid I and his wife Empress Gülüstü Hanım, the daughter of Prince Tahir Bey Chachba and Afise Lakerba. She was the sister of Sultan Mehmed VI and the half sister of the Sultans Murad V, Abdul Hamid II and Mehmed V.

Mediha Sultan was born as the daughter of Sultan Abdülmecid I and his wife Empress Gülüstü Hanım. She was the sister of Mehmed VI and the half sister of the Sultans Murad V, Abdul Hamid II and Mehmed V. After the death of her mother she was given to Empress Verdicenan Kadın, to raise. She was fond of European ways. She dressed beautifully and with great dignity appearing splendidly regal in her gowns with their long trains. She was petite with white skin and gorgeous black eyes, and she too resembled Sultan Abdülmecid. In manner she was gracious, attractive, and wonderfully kind. Everyone in the palace loved this princess. As did Princess Seniha Sultan, she too spoke laughingly, with an air of good humor in her voice. When these two sisters were together chatting with Mehmed V, they would both laugh and try to amuse him and get him to smile as though they were in competition with one another.

When she grew up, she fell in love with Necip Pasha, son of Sheikh Necipzade Sami Bey and wanted to marry him. But Abdul Hamid II didn't wanted her to marry him. At last Verdicenan gave her permission to marry him. In 1879 Princess Mediha married Necib Pasha. They had a son, Prince Sami Bey, who later became personal aide-de-camp to Abdul Hamid and served in the Ertuğrul Regiment. As a member of the entourage of Prince Abdülkadir Efendi, he participated in ceremonial occasions and at the Royal Mosque Processions each Friday, following on horseback behind Abdul Hamid. After Necib Pasha died Princess Mediha married Ferid Pasha, but no children came of this marriage. Princess Mediha died on 7 January 1928 in Nice, France.

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