Maria Antonia Ferdinanda of Spain (María Antonia Fernanda; 17 November 1729 – 19 September 1785) was an Infanta of Spain and the youngest daughter of Philip V of Spain and Elisabeth Farnese. She was the wife of Victor Amadeus III of Sardinia whom she married in 1750. She was the mother of the last three mainline Kings of Sardinia.

She was born at the Royal Alcázar of Seville in Seville and was the youngest daughter of Philip V of Spain and of his second wife Elisabeth Farnese. She was born in Seville during the signing of the Treaty of Seville which ended the Anglo-Spanish War. She spent her infancy in the city of her birth before moving to Madrid in 1733. She was baptised with the names María Antonia along with Fernanda in honour of her half brother, then the heir to the throne. Variations in her name range from "Antonia Fernanda" and "Antonietta Ferdinanda". As a daughter of the King of Spain, she held the title of Infanta of Spain and style of Royal Highness.

In a double marriage plan she would marry Louis, Dauphin of France, and her brother, Infante Philip, would marry the Dauphin's sister Louise Élisabeth of France. Her mother consented to the latter union but insisted on waiting for Maria Antonia Ferdinanda to reach a more mature age. The Infanta's hand was also sought by the Electoral Prince of Saxony. The marriage between Infante Philip and Louise Élisabeth occurred in 1739 and eventually her older sister Infanta Maria Teresa Rafaela married the Dauphin in 1745. However, upon the death of Maria Teresa Rafaela in 1746Ferdinand VI tried to engage Maria Antonia Fernandina to the Dauphin but the idea was snubbed by Louis XV as "incest". Instead he chose Maria Josepha of Saxony.

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