Marguerite Vogt

Marguerite Vogt (13 February 1913 – 6 July 2007) was a cancer biologist and virologist. She was most noted for her research on polio and cancer at the Salk Institute for Biological Studies.

Marguerite Vogt was born in Germany in 1913. The youngest daughter of Oskar Vogt and French-born Cécile Vogt-Mugnier, Marguerite took her M.D. degree from the University of Berlin in 1937. Her parents were prominent neuroscientists and she grew up in an intense scientific environment. Her older sister, Marthe Vogt (1903-2003) was a neuropharmacologist who became a fellow of the Royal Society and a professor at Cambridge.

Marguerite Vogt joined her parents at a private institute in Neustadt, the Black Forest, where the family lived for the duration of World War II; there, she worked extensively on Drosophila development. She published over 30 papers on the ring gland and homeotic mutants .

Marguerite moved to the California Institute of Technology in 1950 to work with Max Delbrück. He introduced her to Renato Dulbecco, a junior faculty member in the division of biology and together, Vogt and Dulbecco worked on methods to culture poliovirus. They were the first to successfully grow the virus in vitro and were able to plaque purify it, an essential step for subsequent vaccine production. Marguerite's technical abilities as a cell culturist were critical to this work. This resulted in a classic paper. They next turned their attention to cancer causing viruses, beginning with the polyoma virus. They were able to culture this virus and examine its latency, resulting in another classic study.

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