Manuel Poggiali (Italian pronunciation: [ˈmanuel podˈdʒali]; born February 14, 1983) is a Grand Prix motorcycle road racing World Champion from San Marino. He was the 2001 125cc World Champion, and the 2003 250cc World Champion. He scored 12 race wins, 11 pole positions, and 35 podium finishes. He often struggled with motivation and the mental side of racing, and this contributed to his early retirement from the sport.

Poggiali began racing Minibikes in 1994, and made his first Grand Prix starts in 1998, also winning the Italian 125cc Championship that year. He went into the 125cc World Championship full-time in 1999, and showed promise over the next two years, scoring a first podium at Assen in 2000. In 2001 he improved to win the title on a Gilera. He remained in the class in 2002, scoring 7 podiums in the first 8 races but failing to defend his title, losing out to Arnaud Vincent.

For 2003 he moved up to 250s, and followed Freddie Spencer and Tetsuya Harada in winning the title at his first attempt, including victories in the season's first two races. He had a disappointing 2004 however, finishing only 9th overall with just three podium results.

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