MYST2

KAT7

Identifiers

KAT7, HBO1, HBOA, MYST2, ZC2HC7, lysine acetyltransferase 7

External IDs

Gene ontology
Molecular function	• transferase activity • transferase activity, transferring acyl groups other than amino-acyl groups • transcription factor activity, sequence-specific DNA binding • zinc ion binding • metal ion binding • histone acetyltransferase activity • protein binding • transferase activity, transferring acyl groups
Cellular component	• nucleoplasm • nucleolus • histone acetyltransferase complex • nucleus • cytosol
Biological process	• regulation of transcription, DNA-templated • transcription, DNA-templated • histone H4-K5 acetylation • DNA replication • histone H3 acetylation • histone H4-K16 acetylation • histone H4-K8 acetylation • histone H4-K12 acetylation • positive regulation of protein localization to nucleus • covalent chromatin modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


11143


217127


ENSG00000136504


ENSMUSG00000038909


O95251


Q5SVQ0

RefSeq (mRNA)

NM_001199155 NM_001199156 NM_001199157 NM_001199158 NM_007067
NM_001346706


NM_001195003 NM_001195004 NM_177619

RefSeq (protein)

NP_001186084 NP_001186085 NP_001186086 NP_001186087 NP_001333635
NP_008998


NP_001181933.1 NP_808287.1 NP_001181932 NP_001181933 NP_808287

Location (UCSC)

PubMed search

Histone acetyltransferase KAT7 is an enzyme that in humans is encoded by the KAT7 gene. It specifically acetylates H4 histones at the lysine12 residue (H4K12) and is necessary for origin licensing and DNA replication. KAT7 associates with origins of replication during G1 phase of the cell cycle through complexing with CDT1.Geminin is thought to inhibit the acetyltransferase activity of KAT7 when KAT7 and CDT1 are complexed together.