DNA replication factor CDT1

CDT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LE8, 2WVR
Identifiers
Aliases	CDT1, DUP, RIS2, chromatin licensing and DNA replication factor 1
External IDs	MGI: 1914427 HomoloGene: 32650 GeneCards: CDT1
Gene location (Human) Chr. Chromosome 16 (human) Band 16q24.3 Start 88,803,213 bp End 88,809,258 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E1 Start 122,568,015 bp End 122,573,554 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • protein binding • chromatin binding Cellular component • cytosol • nucleus • nucleoplasm • nuclear body • chromosome, centromeric region • condensed chromosome kinetochore • chromosome • kinetochore • cytoplasm Biological process • DNA replication checkpoint • G1/S transition of mitotic cell cycle • DNA replication • cell cycle • regulation of nuclear cell cycle DNA replication • regulation of transcription involved in G1/S transition of mitotic cell cycle • regulation of DNA-dependent DNA replication initiation • chromosome segregation • attachment of mitotic spindle microtubules to kinetochore • mitotic cell cycle • positive regulation of protein complex assembly • regulation of chromosome organization • positive regulation of chromatin binding • cell division • kinetochore organization • DNA replication preinitiation complex assembly • response to sorbitol • deactivation of mitotic spindle assembly checkpoint • regulation of DNA replication origin binding • negative regulation of protein localization to kinetochore • positive regulation of protein localization to kinetochore • positive regulation of DNA-dependent DNA replication • positive regulation of mediator complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81620	67177
Ensembl	ENSG00000167513	ENSMUSG00000006585
UniProt	Q9H211	Q9H211 Q8R4E9
RefSeq (mRNA)	NM_030928	NM_026014
RefSeq (protein)	NP_112190	NP_112190 NP_080290
Location (UCSC)	Chr 16: 88.8 – 88.81 Mb	Chr 16: 122.57 – 122.57 Mb
PubMed search

2LE8, 2WVR

81620

67177

ENSG00000167513

ENSMUSG00000006585

Q9H211

Q9H211
Q8R4E9

NM_030928

NM_026014

NP_112190

NP_112190
NP_080290

DNA replication factor Cdt1 is a protein that in humans is encoded by the CDT1 gene.

The protein encoded by this gene is a key licensing factor which, along with the protein Cdc6, functions to license DNA by forming the pre-replication complex (pre-RC). Its activity during the cell cycle is tightly regulated by its association with the protein geminin, which both inhibits Cdt1 activity during S phase in order to prevent re-replication of DNA and prevents it from ubiquitination and subsequent proteolysis.

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Wikipedia