MYLK3

MYLK3
Identifiers
Aliases	MYLK3, MLCK, MLCK2, caMLCK, myosin light chain kinase 3
External IDs	MGI: 2443063 HomoloGene: 35278 GeneCards: MYLK3
Gene ontology Molecular function • calmodulin-dependent protein kinase activity • kinase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • transferase activity • ATP binding • myosin light chain kinase activity Cellular component • cytoplasm • actin cytoskeleton • cytosol • intracellular Biological process • protein phosphorylation • positive regulation of sarcomere organization • regulation of vascular permeability involved in acute inflammatory response • sarcomere organization • cellular response to interleukin-1 • phosphorylation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • intracellular signal transduction • sarcomerogenesis • cardiac myofibril assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	91807	213435
Ensembl	ENSG00000140795	ENSMUSG00000031698
UniProt	Q32MK0	Q3UIZ8
RefSeq (mRNA)	NM_001308301 NM_182493	NM_001297612 NM_175441
RefSeq (protein)	NP_001295230 NP_872299	NP_001284541 NP_780650
Location (UCSC)	Chr 16: 46.7 – 46.79 Mb	Chr 8: 85.32 – 85.39 Mb
PubMed search

91807

213435

ENSG00000140795

ENSMUSG00000031698

Q32MK0

Q3UIZ8

NM_001308301
NM_182493

NM_001297612
NM_175441

NP_001295230
NP_872299

NP_001284541
NP_780650

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.

Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.

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Wikipedia