MYL2

MYL2
Identifiers
Aliases	MYL2, CMH10, MLC2, MLC-2s/v, myosin light chain 2
External IDs	MGI: 97272 HomoloGene: 55462 GeneCards: MYL2
Gene ontology Molecular function • calcium ion binding • actin monomer binding • metal ion binding • myosin heavy chain binding • protein binding • structural constituent of muscle Cellular component • cytoplasm • cytosol • sarcomere • myofibril • actin cytoskeleton • A band • cytoskeleton • myosin complex • cardiac myofibril Biological process • cardiac muscle contraction • positive regulation of the force of heart contraction • regulation of the force of heart contraction • heart morphogenesis • post-embryonic development • cardiac myofibril assembly • ventricular cardiac muscle tissue morphogenesis • heart development • regulation of striated muscle contraction • muscle fiber development • negative regulation of cell growth • muscle filament sliding • muscle cell fate specification • heart contraction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4633	17906
Ensembl	ENSG00000111245	ENSMUSG00000013936
UniProt	P10916	P51667
RefSeq (mRNA)	NM_000432	NM_010861
RefSeq (protein)	NP_000423	NP_034991
Location (UCSC)	Chr 12: 110.91 – 110.92 Mb	Chr 5: 122.1 – 122.11 Mb
PubMed search

4633

17906

ENSG00000111245

ENSMUSG00000013936

P10916

P51667

NM_000432

NM_010861

NP_000423

NP_034991

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B) and cardiac atrial muscle (MYL7).

Ventricular myosin light chain-2 (MLC-2v) refers to the ventricular cardiac muscle form of myosin light chain 2 (Myl2). MLC-2v is a 19-KDa protein composed of 166 amino acids, that belongs to the EF-hand Ca²⁺ binding superfamily. MLC-2v interacts with the neck/tail region of the muscle thick filament protein myosin to regulate myosin motility and function.

Cardiac, ventricular RLC is an 18.8 kDa protein composed of 166 amino acids.RLC and the second ventricular light chain, essential light chain (ELC, MYL3), are non-covalently bound to IQXXXRGXXXR motifs in the 9 nm S1-S2 lever arm of the myosin head, both alpha (MYH6) and beta (MYH7) isoforms. Both light chains are members of the EF-hand superfamily of proteins, which possess two helix-loop-helix motifs in two globular domains connected by an alpha-helical linker.

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Wikipedia