MYH6

Identifiers

MYH6, ASD3, CMD1EE, CMH14, MYHC, MYHCA, SSS3, alpha-MHC, myosin, heavy chain 6, cardiac muscle, alpha, myosin heavy chain 6

External IDs

Gene ontology
Molecular function	• nucleotide binding • actin-dependent ATPase activity • calmodulin binding • ATPase activity • actin binding • motor activity • ATP binding • protein kinase binding • myosin phosphatase activity • microfilament motor activity
Cellular component	• cytoplasm • cytosol • sarcomere • myofibril • myosin filament • muscle myosin complex • myosin complex • stress fiber • Z disc
Biological process	• muscle contraction • ventricular cardiac muscle tissue morphogenesis • ATP metabolic process • muscle filament sliding • atrial cardiac muscle tissue morphogenesis • protein dephosphorylation • in utero embryonic development • regulation of the force of heart contraction • regulation of heart rate • striated muscle contraction • adult heart development • visceral muscle development • regulation of heart contraction • regulation of blood pressure • cardiac muscle hypertrophy in response to stress • actin filament-based movement • myofibril assembly • BMP signaling pathway • regulation of ATPase activity • sarcomere organization • cardiac muscle fiber development • cardiac muscle contraction • canonical Wnt signaling pathway • regulation of heart growth
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4624


17888


ENSG00000197616


ENSMUSG00000040752


P13533


Q02566

RefSeq (mRNA)


NM_002471


NM_001164171 NM_010856

RefSeq (protein)


NP_002462


NP_001157643 NP_034986

Location (UCSC)

PubMed search

Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene. This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is expressed predominantly in human cardiac atria, exhibiting only minor expression in human cardiac ventricles. It is the major protein comprising the cardiac muscle thick filament, and functions in cardiac muscle contraction. Mutations in MYH6 have been associated with late-onset hypertrophic cardiomyopathy, atrial septal defects and sick sinus syndrome.