MUC4

MUC4
Identifiers
Aliases	MUC4, ASGP, HSA276359, MUC-4, mucin 4, cell surface associated
External IDs	GeneCards: MUC4
Gene ontology Molecular function • extracellular matrix constituent, lubricant activity • ErbB-2 class receptor binding Cellular component • Golgi lumen • proteinaceous extracellular matrix • extracellular region • integral component of membrane • vesicle • integral component of plasma membrane • extracellular exosome • membrane • extracellular space • plasma membrane Biological process • cell-matrix adhesion • cell adhesion • maintenance of gastrointestinal epithelium • O-glycan processing • stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4585	n/a
Ensembl	n/a	n/a
UniProt	Q99102	n/a
RefSeq (mRNA)	NM_138299 NM_004532 NM_018406 NM_138297 NM_138298 NM_001322468	n/a
RefSeq (protein)	NP_001309397 NP_004523 NP_060876 NP_612154	n/a
Location (UCSC)	Chr 3: 195.75 – 195.81 Mb	n/a
PubMed search		n/a

4585

n/a

n/a

n/a

Q99102

n/a

NM_001322468

n/a

NP_001309397
NP_004523
NP_060876
NP_612154

n/a

Mucin 4 (MUC 4) is a mucin protein that in humans is encoded by the MUC4 gene. Like other mucins, MUC-4 is a high-molecular weight glycoprotein.

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues.

MUC-4 has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as endometriosis and inflammatory bowel disease. MUC-4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein, and up to 4,650 kDa with glycosylation.

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