MOCS1

MOCS1
Identifiers
Aliases	MOCS1, MIG11, MOCOD, MOCODA, molybdenum cofactor synthesis 1
External IDs	HomoloGene: 129502 GeneCards: MOCS1
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.2 Start 39,899,578 bp End 39,934,551 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • nucleotide binding • 4 iron, 4 sulfur cluster binding • catalytic activity • lyase activity • GTP binding • iron-sulfur cluster binding • GTP 3',8'-cyclase activity • cyclic pyranopterin monophosphate synthase activity Cellular component • molybdopterin synthase complex • cytosol • nucleus Biological process • Mo-molybdopterin cofactor biosynthetic process • molybdopterin cofactor biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4337	n/a
Ensembl	ENSG00000124615	n/a
UniProt	Q9NZB8	n/a
RefSeq (mRNA)	NM_001075098 NM_005942 NM_005943 NM_138928	n/a
RefSeq (protein)	NP_001068566 NP_005934	n/a
Location (UCSC)	Chr 6: 39.9 – 39.93 Mb	n/a
PubMed search		n/a

4337

n/a

ENSG00000124615

n/a

Q9NZB8

n/a

NM_001075098
NM_005942
NM_005943
NM_138928

n/a

NP_001068566
NP_005934

n/a

Molybdenum cofactor biosynthesis protein 1 is a protein that in humans is encoded by the MOCS1 gene.

Both copies of this gene are defective in patients with molybdenum cofactor deficiency, type A.

Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in molybdenum cofactor biosynthesis. (This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA.) Two of the splice variants found for this gene express proteins (MOCS1A-MOCS1B) that result from a fusion between the two open reading frames.

...
Wikipedia