MHC class I polypeptide-related sequence A

MICA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1B3J, 1HYR
Identifiers
Aliases	MICA, MIC-A, PERB11.1, MHC class I polypeptide-related sequence A
External IDs	GeneCards: MICA
Genetically Related Diseases
rheumatoid arthritis
Gene ontology Molecular function • antigen binding • beta-2-microglobulin binding • protein binding • natural killer cell lectin-like receptor binding Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • extracellular space Biological process • antigen processing and presentation • cytolysis • adaptive immune response • negative regulation of natural killer cell activation • immune system process • gamma-delta T cell activation • response to heat • immune response to tumor cell • cellular response to DNA damage stimulus • defense response to bacterium • defense response to virus • regulation of immune response • negative regulation of natural killer cell mediated cytotoxicity • viral process • T cell mediated cytotoxicity • natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	100507436	n/a
Ensembl	n/a	n/a
UniProt	Q29983	n/a
RefSeq (mRNA)	NM_001289154 NM_000247 NM_001177519 NM_001289152 NM_001289153	n/a
RefSeq (protein)	NP_000238 NP_001170990 NP_001276081 NP_001276082 NP_001276083	n/a
Location (UCSC)	Chr 6: 31.4 – 31.42 Mb	n/a
PubMed search		n/a

1B3J, 1HYR

100507436

n/a

n/a

n/a

Q29983

n/a

NM_001289154
NM_000247
NM_001177519
NM_001289152
NM_001289153

n/a

NP_000238
NP_001170990
NP_001276081
NP_001276082
NP_001276083

n/a

MHC class I polypeptide-related sequence A (MICA) is a cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. However, MICA is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do. MICA rather functions as a stress-induced ligand for NKG2D receptor. For example, the heat shock stress pathway is involved in the regulation of MICA expression as transcription of MICA is regulated by promoter heat shock element. MICA is broadly recognized by NK cells, γδ T cells, and CD8⁺ αβ T cells which carry NKG2D receptor on their cell surface. As a result of NKG2D-MICA engagement, effector cytolytic responses of T cells and NK cells against epithelial tumor cells expressing MICA are initiated.

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