MEK2

MAP2K2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S9I, 4H3Q
Identifiers
Aliases	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
External IDs	MGI: 1346867 HomoloGene: 48591 GeneCards: MAP2K2
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • PDZ domain binding • scaffold protein binding • protein serine/threonine kinase activator activity • metal ion binding • kinase activity • protein binding • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • MAP kinase kinase activity • protein serine/threonine kinase activity Cellular component • late endosome • Golgi apparatus • membrane • focal adhesion • cell-cell junction • peroxisomal membrane • extracellular region • early endosome • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • cytoplasmic side of plasma membrane • microtubule • nucleus • cytoplasm • cytosol • plasma membrane Biological process • phosphorylation • regulation of early endosome to late endosome transport • peptidyl-serine autophosphorylation • negative regulation of gene expression • positive regulation of protein serine/threonine kinase activity • protein phosphorylation • activation of MAPK activity • peptidyl-tyrosine phosphorylation • regulation of Golgi inheritance • regulation of stress-activated MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • positive regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of transcription, DNA-templated • proteolysis in other organism • positive regulation of ERK1 and ERK2 cascade • regulation of mitotic cell cycle • regulation of apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5605	26396
Ensembl	ENSG00000126934	ENSMUSG00000035027
UniProt	P36507	Q63932
RefSeq (mRNA)	NM_030662	NM_023138 NM_001347144
RefSeq (protein)	NP_109587	NP_001334073 NP_075627
Location (UCSC)	Chr 19: 4.09 – 4.12 Mb	Chr 10: 81.11 – 81.13 Mb
PubMed search

1S9I, 4H3Q

5605

26396

ENSG00000126934

ENSMUSG00000035027

P36507

Q63932

NM_030662

NM_023138
NM_001347144

NP_109587

NP_001334073
NP_075627

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1.

...
Wikipedia